Endocrine Abstracts

A number of factors including hyperglycaemia, hypertension, dyslipidaemia and oxidative stress contribute to the development of vascular disease in diabetes, the chief cause of the increased morbidity and mortality associated with this disease. Within the vessel wall impairment of endothelial and smooth muscle responses both contribute to functional abnormalities such as reduced vasodilation and it has been shown that hypertension and diabetes have additive effects on vascular...